Blar i NTNU Open på forfatter "Helgesen, Emily"
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Characterization of the Uptake and Trafficking of AvB3-targeted and Non-targeted Nanoemulsions in Human Endothelial Cells in vitro
Helgesen, Emily (Master thesis, 2011)RGD-functionalized and non-functionalized oil-in-water nanoemulsions of approximately 100 nm containing DSPC, PEGylated DSPE, cholesterol and Gd-DTPA-DSA at a molar ratio of 1.1/0.15/1/0.75 were prepared. In vitro uptake ... -
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Sæbø, Ingvill Pedersen; Bjørås, Magnar; Franzyk, Henrik; Helgesen, Emily; Booth, James Alexander (Peer reviewed; Journal article, 2023)In vitro determination of hemolytic properties is a common and important method for preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical device or material. The method itself is ... -
Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis
Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2020)In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ... -
Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli
Helgesen, Emily; Sætre, Frank Ove; Skarstad, Kirsten Jane (Peer reviewed; Journal article, 2021)Topoisomerase IV (TopoIV) is a vital bacterial enzyme which disentangles newly replicated DNA and enables segregation of daughter chromosomes. In bacteria, DNA replication and segregation are concurrent processes. This ...